Teaching morpho-functional sciences requires anatomical specimens, yet traditional preservation with formaldehyde poses health risks. Plastination provides safe, durable samples but faces limitations due to cost and regulatory restrictions on solvents and polymers. This pilot study evaluated ethanol, thinner, and platinum silicone as alternatives for producing plastinated specimens in Ecuador. Von Hagens’ plastination protocol was applied to chicken organs (heart, gizzard, and proventriculus), adapting dehydration–degreasing and forced impregnation phases. Organs were fixed in 10% formaldehyde for 15 days. Alternative solvents (ethanol, acetone, thinner) were tested at -20 °C; ethanol and acetone were selected for minimal volumetric shrinkage. Impregnation compared Biodur® (S10:S3) with platinum silicone, followed by curing with S6 Biodur® or manual catalyst application. Volumetric changes were recorded after dehydration and at process completion. Ethanol and acetone yielded lower shrinkage in hearts (12%) and gizzards (1–3%) versus thinner (43%). From a qualitative macroscopic standpoint, both the organs processed with Biodur® silicones (BS) and those treated with platinum silicone (PS) were dry, odorless, retained their overall anatomical shape, and could be handled without structural damage. However, the present study did not include a standardized scoring system for specimen quality assessment, which represents a limitation and should be addressed in future studies. Besides, the Bayesian statistical analyses performed on volumetric shrinkage did not provide sufficient evidence to indicate differences between the two polymers. Consequently, while these results may suggest possible trend toward the technically feasible of platinum silicone as an alternative, further in-depth studies with larger samples sizes are required. Nevertheless, the findings of this pilot study support the potential feasibility of an alternative dehydration protocol using ethanol.